Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
Identifieur interne : 004636 ( Main/Exploration ); précédent : 004635; suivant : 004637Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
Auteurs : Odile Poulain-Godefroy [France] ; Elodie Eury [France] ; Audrey Leloire [France] ; Benjamin Hennart [France] ; Gilles J. Guillemin [Australie] ; Delphine Allorge [France] ; Philippe Froguel [France, Royaume-Uni]Source :
- International Journal of Tryptophan Research : IJTR [ 1178-6469 ] ; 2013.
Abstract
Low-grade and chronic inflammation is elicited in white adipose tissue in human obesity. The presence of inflammatory molecules leads to an increased tryptophan catabolism through the induction of indoleamine-2,3-dioxygenase-1 (IDO1). In order to characterize the mechanisms underlying this dysregulation, we have studied 2 mouse models of obesity. Unexpectedly, we did not detect any IDO1 expression in obese or lean mice adipose tissue. In a previous study, we did not find any significant difference in the liver for IDO2 and tryptophan-2,3-dioxygenase (TDO2) gene expression between normal weight and obese patients. IDO2 and TDO2 expression was increased in the liver of high-fat fed mice, but not in ob/ob mice, and was strongly correlated with hydroxysteroid-(11-beta) dehydrogenase-1 (HSD11B1) expression, an enzyme that generates active cortisol within tissues. In conclusion, despite a dysregulation of tryptophan metabolism, obese mice display discrepancies with human obesity metabolism, rendering them inappropriate for further investigations in this animal model.
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DOI: 10.4137/IJTR.S11717
PubMed: 26882470
PubMed Central: 3729279
Affiliations:
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Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><affiliation wicri:level="3"><nlm:aff id="af1-ijtr-suppl.1-2013-029">European Genomic Institute for Diabetes (EGID), Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>European Genomic Institute for Diabetes (EGID), Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af2-ijtr-suppl.1-2013-029">University of Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af3-ijtr-suppl.1-2013-029">CNRS UMR 8199, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CNRS UMR 8199, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af4-ijtr-suppl.1-2013-029">CHRU Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CHRU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af5-ijtr-suppl.1-2013-029">IPL, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>IPL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><affiliation wicri:level="3"><nlm:aff id="af2-ijtr-suppl.1-2013-029">University of Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af4-ijtr-suppl.1-2013-029">CHRU Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CHRU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af6-ijtr-suppl.1-2013-029">EA4483, Faculty of Medicine, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>EA4483, Faculty of Medicine, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="af7-ijtr-suppl.1-2013-029">MND and Neurodegenerative Diseases Research Group, Australian School of Advanced Medicine, Macquarie University, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>MND and Neurodegenerative Diseases Research Group, Australian School of Advanced Medicine, Macquarie University</wicri:regionArea><wicri:noRegion>Macquarie University</wicri:noRegion></affiliation></author><author><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><affiliation wicri:level="3"><nlm:aff id="af2-ijtr-suppl.1-2013-029">University of Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af4-ijtr-suppl.1-2013-029">CHRU Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CHRU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af6-ijtr-suppl.1-2013-029">EA4483, Faculty of Medicine, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>EA4483, Faculty of Medicine, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><nlm:aff id="af1-ijtr-suppl.1-2013-029">European Genomic Institute for Diabetes (EGID), Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>European Genomic Institute for Diabetes (EGID), Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af2-ijtr-suppl.1-2013-029">University of Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af3-ijtr-suppl.1-2013-029">CNRS UMR 8199, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CNRS UMR 8199, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af4-ijtr-suppl.1-2013-029">CHRU Lille, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>CHRU Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af5-ijtr-suppl.1-2013-029">IPL, Lille, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>IPL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af8-ijtr-suppl.1-2013-029">Department of Genomics of Common Disease, School of Public Health, Imperial College London, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Genomics of Common Disease, School of Public Health, Imperial College London</wicri:regionArea><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Tryptophan Research : IJTR</title><idno type="eISSN">1178-6469</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Low-grade and chronic inflammation is elicited in white adipose tissue in human obesity. The presence of inflammatory molecules leads to an increased tryptophan catabolism through the induction of indoleamine-2,3-dioxygenase-1 (IDO1). In order to characterize the mechanisms underlying this dysregulation, we have studied 2 mouse models of obesity. Unexpectedly, we did not detect any IDO1 expression in obese or lean mice adipose tissue. In a previous study, we did not find any significant difference in the liver for IDO2 and tryptophan-2,3-dioxygenase (TDO2) gene expression between normal weight and obese patients. IDO2 and TDO2 expression was increased in the liver of high-fat fed mice, but not in ob/ob mice, and was strongly correlated with hydroxysteroid-(11-beta) dehydrogenase-1 (HSD11B1) expression, an enzyme that generates active cortisol within tissues. In conclusion, despite a dysregulation of tryptophan metabolism, obese mice display discrepancies with human obesity metabolism, rendering them inappropriate for further investigations in this animal model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Harford, Ka" uniqKey="Harford K">KA Harford</name></author><author><name sortKey="Reynolds, Cm" uniqKey="Reynolds C">CM Reynolds</name></author><author><name sortKey="Mcgillicuddy, Fc" uniqKey="Mcgillicuddy F">FC McGillicuddy</name></author><author><name sortKey="Roche, Hm" uniqKey="Roche H">HM Roche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Fox, Cs" uniqKey="Fox C">CS Fox</name></author><author><name sortKey="Hickson, Da" uniqKey="Hickson D">DA Hickson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolowczuk, I" uniqKey="Wolowczuk I">I 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Villella</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name></region><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><name sortKey="Eury, Elodie" sort="Eury, Elodie" uniqKey="Eury E" first="Elodie" last="Eury">Elodie Eury</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name></country><country name="Australie"><noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
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|texte= Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
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